Logo

Ocular Behçet’s disease is less complicated with allergic disorders. A nationwide survey in Japan

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30

  1. Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan.
  2. Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, and Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  3. Department of Ophthalmology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
  4. Department of Ophthalmology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
  5. Department of Ophthalmology, Osaka University, Japan.
  6. Department of Ophthalmology Tokyo Medical University, Japan.
  7. Department of Ophthalmology Tokyo Medical University, Japan.
  8. Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan.
  9. Yoshinocho Eye Clinic, Yokohama, Japan.
  10. Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
  11. Department of Ophthalmology, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
  12. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  13. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.
  14. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.
  15. Department of Ophthalmology, Nippon Medical School, Tokyo, Japan.
  16. Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
  17. Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
  18. Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
  19. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
  20. Department of Ophthalmology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
  21. Department of Ophthalmology, Jichi Medical University, Shimotsuke, Japan.
  22. Department of Ophthalmology and Visual Science, Kochi University, Nankoku, Japan.
  23. Department of Ophthalmology, Ehime University Graduate School of Medicine, Matsuyama, Japan.
  24. Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.
  25. Department of Ophthalmology, Keio University School of Medicine, Japan.
  26. Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  27. Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  28. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  29. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  30. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

CER9574 Submission on line
2016 Vol.34, N°6 ,Suppl.102 - PI 0111, PF 0114
Full Papers

Free to view (click on article PDF icon to read the article)

Rheumatology Article

 

Abstract

OBJECTIVES:
Behçet’s disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD.
METHODS:
The study involved a large-scale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study. We analysed the history of allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA) and drug/food allergies (FA).
RESULTS:
Oral aphthous ulcers, ocular lesions, skin lesions, genital ulcers, arthritis, neurological lesions, intestinal lesions, deep vein thrombosis and epididymitis were reported in 95.8%, 98.6%, 72.5%, 44.8%, 13.9%, 6.8%, 6.2%, 3.7% and 1.4% of the patients, respectively. It was also reported that 73 patients (20.7%) had histories of allergic diseases: AD (5 cases, 1.4%), AR (36 cases, 10.2%), BA (19 cases, 5.4%) and FA (30 cases, 8.5%). This percentage was significantly lower than in a survey that Japan’s Ministry of Health, Labour and Welfare conducted for healthy population (47.6%) (odds ratio = 0.29, 95% confidence interval = 0.22-0.38, p=4.9×10-22). Frequencies of posterior/pan-uveitis, relatively severe ocular findings, and visual prognosis were not affected by a history of allergic diseases in BD.
CONCLUSIONS:
Patients with BD had fewer complications from allergic diseases than did the entire population of Japan.

PMID: 27791954 [PubMed]

Received: 11/05/2016 - Accepted : 19/09/2016 - In Press: 25/10/2016 - Published: 25/10/2016