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An update on the animal models in hyperuricaemia research

1, 2, 3

  1. Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China. 463905719@qq.com
  2. Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  3. Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

CER10063 Submission on line
2017 Vol.35, N°5 - PI 0860, PF 0864
Review

Rheumatology Article

 

Abstract

Hyperuricaemia is a metabolic disease caused by purine metabolic abnormalities, mainly due to the increased formation or reduced excretion of uric acid. In recent years, it has been proved that hyperuricaemia is an important risk factor for chronic kidney disease (CKD) and cardiovascular disease, and it also takes part in the pathophysiology of metabolic syndrome. In addition, more attention has been concentrated on the pathogenesis or treatment of hyperuricaemia. Since establishing an animal model on hyperuricaemia is the foundation for further researches, several methods to establish the hyperuricaemia model have been developed. In this article, remarkable progress on the modelling approach are summarised, and a comparison study on different methods of developing hyperuricaemia animal models was conducted.

PMID: 28516889 [PubMed]

Received: 02/11/2016 - Accepted : 10/03/2017 - In Press: 08/05/2017 - Published: 15/09/2017