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Infliximab for uveitis of Behçet’s syndrome: a trend for earlier initiation

1, 2, 3, 4, 5, 6, 7, 8, 9

  1. Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  2. Department of Ophthalmology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  3. Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  4. Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  5. Department of Ophthalmology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  6. Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  7. Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  8. Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
  9. Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey. vhamuryudan@yahoo.com

CER10620 Submission on line
2017 Vol.35, N°6 ,Suppl.108 - PI 0086, PF 0089
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Rheumatology Article

 

Abstract

OBJECTIVES:
The prognosis of uveitis in Behçet’s syndrome (BS) has improved over decades. Whether this is related to the use of more aggressive management strategies is not known.
METHODS:
This is a retrospective study of BS patients who received infliximab (IFX) for refractory eye disease between 2003-2015. The patients were divided into two groups according to the date of onset of in IFX treatment as before and after 2013. We compared the two groups in terms of disease characteristics at the onset of IFX treatment and response to treatment.
RESULTS:
There were 43 patients in the old and 14 patients in the new group. The duration of uveitis and previous immunosuppressive treatment before the initiation of IFX were significantly shorter in the new group compared to the old group (p=0.043 and p=0.028, respectively). The baseline visual acuity (VA) at the initiation of IFX was better in the new group, but this was only significant for the left eye. Treatment with IFX was effective in both groups in preserving VA and this was more pronounced in the new group. Attack frequency under IFX was significantly lower in the new group (p<0.001).
CONCLUSIONS:
IFX seems to be initiated earlier and also in less severe cases during the course of BS uveitis than before. Despite the few numbers of patients and relatively short duration of follow-up, our results give a hint that this change has improved the outcome.

PMID: 29148418 [PubMed]

Received: 13/06/2017 - Accepted : 21/09/2017 - In Press: 24/10/2017 - Published: 27/11/2017