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Predict rheumatoid arthritis conversion from undifferentiated arthritis with dynamic contrast-enhanced MRI and laboratory indexes

1, 2, 3, 4

  1. Department of Radiology, Tianjin First Center Hospital, Tianjin, China. leixinwei66@163.com
  2. Department of Radiology, Tianjin First Center Hospital, Tianjin, China.
  3. Department of Radiology, Tianjin First Center Hospital, Tianjin, China.
  4. Department of Radiology, Tianjin First Center Hospital, Tianjin, China.

CER10765 Submission on line
Full Papers

Rheumatology Article

 

Abstract

OBJECTIVES:
To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA).
METHODS:
A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. The DCE-MRI and laboratory measures were fed into a logistic regression analysis.
RESULTS:
Wash-in rate and anti-cyclic citrullinated peptide (anti-CCP) antibody served as the final variables into the regression equation (p<0.05). The area under the ROC curve of wash-in rate was 0.966. With optimal cut-off point 29.84 s-1, wash-in rate achieved a sensitivity of 94.6% and specificity of 88.6% for predicting RA conversion from UA; anti-CCP antibody positive achieved a sensitivity of 37.8% and specificity of 90.9%. The combination of wash-in rate and anti-CCP antibody positive improved specificity (100%) but not sensitivity (27.3%).
CONCLUSIONS:
The conversion from UA to RA is highly predictable. The wash-in rate of DCE-MRI can be used as an important biomarker to predict UA progression.

PMID: 29352841 [PubMed]

Received: 26/08/2017 - Accepted : 25/10/2017 - In Press: 15/01/2018