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Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings

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CER325 Submission on line
2009 Vol.27, N°2 ,Suppl.53 - PI 0073, PF 0078
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Rheumatology Article

 

Abstract

The association of the cytokine gene polymorphisms with the development of Behçet`s Disease (BD) was investigated in this study. DNA samples were obtained from a Turkish population of 97 unrelated patients with BD, and 127 unrelated healthy control subjects. All genotyping (IL-6, IL10, IFN-γ, TGF-β1 and TNF-α) experiments were performed using sequence-specific primers PCR. The frequency of TGF-β1 codon 25 GG genotype was found significantly lower in BD patients compared to healthy control subjects. The IL-10 -1082 GA genotype was more frequent whereas the AA genotype was less common in the BD group compared to the control group. The association between clinial findings and cytokine gene polymorphisms was further investigated in the patients with BD. The frequency of IFN-γ AA genotype was lower in the patients with genital ulcer. Additionally, it was found that the frequency of IL-6 -174 GG genotype was lower in the patients with Pathergy positivity. These results suggest that TGF-β1 and IL-10 gene polymorphisms may affect host susceptibility to BD. Also, to confirm the biological significance of our results, further studies should be performed on other population groups and in large number of cases.

PMID: 19796538 [PubMed]

Received: 31/03/2009 - Accepted : 15/07/2009 - In Press: 02/12/2009 - Published: 02/12/2009