A. Mameli, A. Cauli, E. Taccari, R. Scarpa, L. Punzi, G. Lapadula, R. Peluso, R. Ramonda, A. Spadaro, F. Iannone, V. Fanni, A. Vacca, G. Passiu, M.T. Fiorillo, C. Carcassi, R. Sorrentino, A. Mathieu
2nd Chair of Rheumatology and Rheumatology Unit, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
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Analysis of the association between psoriatic arthritis (PsA) clinical forms and MICA gene transmembrane polymorphisms.
Patients were classified as having peripheral asymmetric oligoarthritis (AO), peripheral symmetric poly-arthritis (PA) and spondylitis (SP), or disease combinations (PA/SP, OA/SP). Two hundred and twenty-six patients with PsA were typed for MICA exon 5 microsatellite (TM) by heteroduplex analysis and compared with 225 normal controls.
MICA-TM microsatellite typing revealed that, among the different clinical forms of PsA, only the combined PA/SP subset shows a significant positive association with MICA-A9 and a lower frequency of MICA-A4, A5 genotype in PsA patients with a decrease, only in the PA/SP cohort, of all MICA-A5 combinations except MICA-A5, -A9.
These results suggest a role for genes within the HLA region in the pathogenesis of PsA, and reinforce the idea that the different forms of PsA may have heterogeneous genetic basis.
PMID: 18799098 [PubMed]