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Genetic association of HLA-A*2601 with ocular Behçet's disease in Japanese patients

, , , , , , , ,

Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan. kabutosi-tky@umin.ac.jp

CER3705 Submission on line
2010 Vol.28, N°4 ,Suppl.60 - PI 0039, PF 0044
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Rheumatology Article

 

Abstract

OBJECTIVES:
Behçet`s disease (BD) is known to be associated with HLA-B*51, especially HLA-B*5101, in many different ethnic groups. Recently, several HLA-A or -B alleles have been proposed as possible candidate genes for BD in addition to HLA-B*5101. To investigate those associations, we studied HLA-A and -B alleles in Japanese ocular BD patients and the association of possible susceptibility HLA genes with visual prognosis.
METHODS:
Eighty-eight Japanese BD patients with uveitis and 104 healthy controls were enrolled for analyses of HLA-A and B alleles. Statistical analysis was performed with Fisher`s exact test and odds ratio (OR). Association of the possible susceptible HLA gene and visual prognosis was also examined.
RESULTS:
The phenotype frequency (PF) of HLA-A*2601 was significantly higher in the patients (37.5%) than the controls (14.4%) (pc=0.00529, OR=3.56), especially in patients without HLA-B*5101 (57.4% vs. 14.1%, pc=4.58x10-6, OR=8.21). In contrast, the PF of HLA-A*2601 was not increased in patients with HLA-B*5101 (14.6% vs. 15.8%). Also, the PF in patients possessing HLA-A*2601 or HLAB* 5101 was increased up to 77.3%. Interestingly, the PF of HLA-A*2601 was significantly associated with poor visual prognosis corresponding to visual acuity of 0.1 or less in the worse eye (p=0.0262).
CONCLUSIONS:
Our results indicate that HLA-A*2601 is possibly associated with ocular BD, independent of HLAB* 5101, indicating that HLA-A*2601 is an additional susceptibility allele candidate of ocular BD in Japan. HLAA* 2601 would also be a possible marker for poor visual prognosis.

PMID: 20868569 [PubMed]

Received: 16/03/2010 - Accepted : 14/05/2010 - In Press: 23/09/2010 - Published: 23/09/2010