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Unusual cardiovascular events in Behçet's disease

, , , ,

Department of Internal Medicine, Bichat-Claude Bernard Hospital, APHP, Paris-7 University, Paris, France. sacrekarim@yahoo.fr

CER3825 Submission on line
2010 Vol.28, N°4 ,Suppl.60 - PI 0082, PF 0085
Case Report

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Rheumatology Article

 

Abstract

OBJECTIVES:
To report on cardiovascular involvement in Behçet`s disease (BD).
METHODS:
A retrospective analysis of clinical, EKG, echodoppler, CT-scan, MRI, conventional angiography, treatment and follow-up data was undertaken in 4 patients suffering BD.
RESULTS:
Cardiac specific complications included coronary artery involvement (n=3), endomyocardial fibrosis (n=1), left ventricle spontaneous rupture with giant wall pseudo-aneurysm (n=1), and massive left ventricle thrombosis (n=1). Follow-up ranged from 1 month to 17 years. Surgery was complicated with vascular patch leakage, recurrent pseudo-aneurysm or upper-limb venous thrombosis in 2 patients who did not receive pre-operative specific treatment because of delayed BD diagnosis. High-dose steroids (n=4), colchicine (n=4), immunosuppressants (n=3) and anticoagulants (n=4) were eventually prescribed and stabilised cardiac disease in all cases.
CONCLUSIONS:
At time of life-threatening cardiac complications, BD was often overlooked. Prompt initiation of steroids and immunosuppressive treatment may prevent post-operative complications, recurrences and death.

PMID: 20868577 [PubMed]

Received: 02/05/2010 - Accepted : 23/06/2010 - In Press: 24/09/2010 - Published: 24/09/2010