Efficacy of adalimumab in patients with Behçet's disease unsuccessfully treated with infliximab

, , , , , , ,

Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza and Matera, Italy. ignazioolivieri@tiscalinet.it

CER4808 Submission on line
2011 Vol.29, N°4 ,Suppl.67 - PI 0054, PF 0057
Full Papers

Free to view (click on article PDF icon to read the article)

Rheumatology Article



To evaluate the clinical response after switching from infliximab to adalimumab in patients with Behçet`s disease (BD). Methods: In this ongoing, prospective, longitudinal and observational study, data were collected on efficacy and safety of every patient with BD beginning anti-TNF therapy in the last 8 years. The present analysis was restricted to patients who were switched to adalimumab after failing or not tolerating infliximab.
A total of 69 patients with BD have been treated with infliximab so far. Seventeen of these (25%) have been switched to adalimumab for lack or loss of efficacy or infusion reactions. In 10 out of these 17, the main manifestations requiring switching were the mucocutaneous lesions, in 4 retinal vasculitis and in 3 the neurological involvement. Of the 17 treated patients, 9 showed sustained remission of the disease and 3 a good response. No side effects were observed in any patient.
The results of our study suggest that patients with BD showing a scarce response or adverse events to infliximab may successfully be treated with adalimumab, regardless of the reason for switching.

PMID: 21968237 [PubMed]

Received: 03/06/2011 - Accepted : 25/08/2011 - In Press: 27/09/2011 - Published: 27/09/2011