S. Sohn, E. Lee, D. Bang
Laboratory of Cell Biology, Ajou University School of Medicine, Suwon, Korea. firstname.lastname@example.org
2012 Vol.30, N°3 ,Suppl.72 - PI 0096, PF 0103
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Several animal models of Behçet`s disease (BD) have been proposed according to putative etiology. Among these models, the herpes simplex virus (HSV)-induced model produced the most similar disease attributes observe in patients. Inoculation of HSV type 1 to the scratched earlobe of mice produced the appropriate symptoms, including oral, genital, and skin ulcers, eye lesions, arthritis, and intestinal involvement. This HSV-induced BD model is the only continuously used model, to which various therapeutic modalities have been applied.
PMID: 22766172 [PubMed]
Received: 19/09/2011 - Accepted : 29/11/2011 - In Press: 25/09/2012 - Published: 19/11/2012