Learning from HSV-infected mice as a model of Behçet's disease

, ,

Laboratory of Cell Biology, Ajou University School of Medicine, Suwon, Korea. sohnsh@ajou.ac.kr

CER5106 Submission on line
2012 Vol.30, N°3 ,Suppl.72 - PI 0096, PF 0103

Free to view (click on article PDF icon to read the article)

Rheumatology Article



Several animal models of Behçet`s disease (BD) have been proposed according to putative etiology. Among these models, the herpes simplex virus (HSV)-induced model produced the most similar disease attributes observe in patients. Inoculation of HSV type 1 to the scratched earlobe of mice produced the appropriate symptoms, including oral, genital, and skin ulcers, eye lesions, arthritis, and intestinal involvement. This HSV-induced BD model is the only continuously used model, to which various therapeutic modalities have been applied.

PMID: 22766172 [PubMed]

Received: 19/09/2011 - Accepted : 29/11/2011 - In Press: 25/09/2012 - Published: 19/11/2012