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New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children

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, , , , , ,

Department of Pediatrics, University of Chieti, Chieti, Italy. gasparistefania@libero.it

CER6257 Submission on line
2013 Vol.31, N°5 - PI 0788, PF 0794
Review

Rheumatology Article

 

Abstract

Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15–30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflammatory pathways have been proposed as mechanisms involved in recurrences. Therapeutic strategies are not standardised, non-steroidal anti-inflammatory drugs at high dosages being the mainstay of therapy with the possible addition of low dose colchicine to prevent recurrences. Biological agents are considered a possible new therapeutic frontiers in the care of idiopathic recurrent pericarditis.

PMID: 23981280 [PubMed]

Received: 10/01/2013 - Accepted : 03/04/2013 - In Press: 02/08/2013 - Published: 19/09/2013