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CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients

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UMIB, Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal. ambettencourt@icbas.up.pt

CER7253 Submission on line
2014 Vol.32, N°4 ,Suppl.84 - PI 0072, PF 0074
Full Papers

Rheumatology Article

 

Abstract

OBJECTIVES:
To investigate whether CCR5 deletion is associated with susceptibility to Behçet`s disease (BD) in a Portuguese population.
METHODS:
A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing.
RESULTS:
No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences.
CONCLUSIONS:
These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.

PMID: 25268662 [PubMed]

Received: 13/01/2014 - Accepted : 14/04/2014 - In Press: 30/09/2014 - Published: 30/09/2014