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Association of CCR5Δ32 and Behçet’s disease: new data from a case-control study in the Spanish population and meta-analysis

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19

  1. Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
  2. Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
  3. Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
  4. Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain.
  5. Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain.
  6. Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
  7. Servicio de Enfermedades Autoinmunes, Hospital Clinic, Barcelona, Spain.
  8. Servicio de Reumatología, Complejo Hospitalario Universitario, A Coruña, Spain.
  9. Servicio de Reumatología, Hospital Universitario de Valme, Sevilla, Spain.
  10. Servicio de Inmunología, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
  11. Servicio de Reumatología, Hospital Marqués de Valdecilla, Santander, Spain.
  12. Servicio de Medicina Interna, Hospital de Torrecárdenas, Almería, Spain.
  13. Servicio de Medicina Interna, Hospital Vall d’Hebron, Barcelona, Spain.
  14. Servicio de Medicina Interna, Hospital Virgen del Camino, Pamplona, Spain.
  15. Servicio de Medicina Interna, Hospital Universitari Mútua, Terrassa, Spain.
  16. Servicio de Medicina Interna, Hospital Universitario Carlos Haya, Málaga, Spain.
  17. Servicio de Reumatología, Hospital de la Princesa, Madrid, Spain.
  18. Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain.
  19. Servicio de Inmunología, IBiS, Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain. mariaf.gonzalez.sspa@juntadeandalucia.es

CER8341 Submission on line
2015 Vol.33, N°6 ,Suppl.94 - PI 0096, PF 0100
Full Papers

Rheumatology Article

 

Abstract

OBJECTIVES:
Behçet’s disease (BD) is an immune-mediated and complex disease associated with HLA class I and other genes. The aim of this study was to contribute to a better understanding of the relationship of the 32-bp deletion in the CCR5 gene (CCR5Δ32) and this disease by conducting a case-control study in the Spanish population and also a meta-analysis including all the studies available to date.
METHODS:
A cohort composed of 348 BD Spanish patients and 477 unrelated healthy and ethnically matched individuals were genotyped in CCR5Δ32 using polymerase chain reaction (PCR) and capillary electrophoresis with fluorescent detection. In the meta-analysis, data from a total of seven populations extracted from four previous studies along with data of the present study were included.
RESULTS:
Regarding the case-control study, no statistically significant differences were observed when the patient and control groups were compared (allelic model: 0.07 in patients vs. 0.06 in controls, p=0.303). In the meta-analysis, no evidence of association of the CCR5Δ32 polymorphism with BD was observed (pMH= 0.091; OR= 1.22; 95%CI 0.98 to 1.52 in the allelic model).
CONCLUSIONS:
The results of this meta-analysis discard a major role of the CCR5Δ32 polymorphism in BD.

PMID: 26393284 [PubMed]

Received: 03/02/2015 - Accepted : 04/06/2015 - In Press: 22/09/2015 - Published: 04/11/2015