K. Kajikhina1, M. Tsuneto2, F. Melchers3
Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany.
2015 Vol.33, N°4 ,Suppl.92 - PI 0091, PF 0093
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In human and murine embryonic development, haematopoiesis and B-lymphopoiesis show stepwise differentiation from pluripotent haematopoietic stem cells and multipotent progenitors, over lineage-restricted lymphoid and myeloid progenitors to B-lineage committed precursors and finally differentiated pro/preB cells. This wave of differentiation is spatially and temporally organised by the surrounding, mostly non-haematopoietic cell niches. We review here recent developments and our current contributions on the research on blood cell development.
PMID: 26457725 [PubMed]
Received: 03/09/2015 - Accepted : 03/09/2015 - In Press: 12/10/2015 - Published: 14/10/2015