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Environments of hematopoiesis and B-lymphopoiesis in foetal liver

1, 2, 3

  1. Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany.
  2. Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany; and Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine, Tsu, Japan.
  3. Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany. melchers@mpiib-berlin.mpg.de

Max Planck Fellow Research Group on “Lymphocyte Development”, Max Planck Institute for Infection Biology, Berlin, Germany.

CER8932 Submission on line
2015 Vol.33, N°4 ,Suppl.92 - PI 0091, PF 0093
Special Lecture

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Rheumatology Article

 

Abstract

In human and murine embryonic development, haematopoiesis and B-lymphopoiesis show stepwise differentiation from pluripotent haematopoietic stem cells and multipotent progenitors, over lineage-restricted lymphoid and myeloid progenitors to B-lineage committed precursors and finally differentiated pro/preB cells. This wave of differentiation is spatially and temporally organised by the surrounding, mostly non-haematopoietic cell niches. We review here recent developments and our current contributions on the research on blood cell development.

PMID: 26457725 [PubMed]

Received: 03/09/2015 - Accepted : 03/09/2015 - In Press: 12/10/2015 - Published: 14/10/2015