21 October 2014
 

Successful use of anakinra to treat refractory Schnitzler`s syndrome

Rheumatology ArticleF. Dybowski, N. Sepp, H.J. Bergerhausen, J. Braun

Rheumazentrum Ruhrgebiet, St. Josef Krankenhaus, Herne, Germany

CER3263
Case Report

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Abstract

ABSTRACT: Schnitzler`s syndrome is a rather rare disease which may appear in a rheumatologist`s office because patients often report rheumatic symptoms with joint, bone and muscle pain. However, it is characterized by chronic urticaria, recurrent fever, liver and spleen enlargement, osteosclerosis, and lymphadenopathy, in conjunction with a serum IgM M component. A patient who had been treated with relatively high doses of corticosteroids for 10 years with insufficient response was treated with the IL-1 receptor antagonist anakinra, this led to a complete resolution of symptoms.

PMID: 18565263 [PubMed]

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