How does methotrexate suppress inflammation?

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Rheumatology ArticleB. Cronstein

NYU School of Medicine, New York, USA. bruce.cronstein@nyumc.org

CER3959 Submission on line 2010 Vol.28, N°5 ,Suppl.61 - PI 0021, PF 0023


Methotrexate remains the most widely used agent for the treatment of rheumatoid arthritis and other chronic inflammatory diseases. Although introduced as a chemotherapeutic agent for the treatment of malignancies, it is clear that, in the doses used, the mechanism of action in the suppression of inflammation differs from simply suppression of purine and pyrimidine metabolism, resulting in inhibition of proliferation. Here we review the proposed mechanisms of action of methotrexate.

PMID: 21044428 [PubMed]

Received: 28/06/2010 - Accepted : 01/09/2010 - In Press: 28/10/2010 - Published: 28/10/2010