02 September 2014
 

Organ-specific autoantibodies and autoimmune diseases in juvenile systemic lupus erythematosus and juvenile dermatomyositis patients.

Purchase this article

Rheumatology ArticleN. Aikawa, A. Jesus, B. Liphaus, C. Silva, M. Carneiro-Sampaio, V. Viana, A. Sallum

Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de Sao Paulo, Brazil. nadia.aikawa@gmail.com

CER4604 Submission on line
Pediatric Rheumatology

Abstract

OBJECTIVES:
To our knowledge, no study assessed simultaneously a variety of organ-specific autoantibodies and the prevalence of organ-specific autoimmune diseases in juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM). Therefore, the purpose of this study was to evaluate organ-specific autoantibodies and autoimmune diseases in JSLE and JDM patients.
METHODS:
Forty-one JSLE and 41 JDM patients were investigated for autoantibodies associated with autoimmune hepatitis, primary biliary cirrhosis, type 1 diabetes mellitus (T1DM), autoimmune thyroiditis (AT), autoimmune gastritis and coeliac disease (CD). Patients with positive antibodies were investigated for the respective organ-specific autoimmune diseases.
RESULTS:
Mean age at diagnosis was higher in JSLE compared to JDM patients (10.33.4 vs. 7.33.1years, p=0.0001). The frequencies of organ-specific autoantibodies were similar in JSLE and JDM patients (p>0.05). Of note, a high prevalence of T1DM and AT autoantibodies was observed in both groups (20% vs. 15%, p=0.77 and 24% vs. 15%, p=0.41; respectively). Higher frequencies of ANA (93% vs. 59%, p=0.0006), anti-dsDNA (61% vs. 2%, p<0.0001), anti-Ro, anti-Sm, anti-RNP, anti-La and IgG-aCL were observed in JSLE (p<0.05). Organ-specific autoimmune diseases were evidenced only in JSLE patients (24% vs. 0%, p=0.13). Two JSLE patients had T1DM associated with Hashimoto thyroiditis and another had subclinical thyroiditis. Another JSLE patient had CD diagnosis based on iron deficiency anaemia, anti-endomysial antibody, duodenal biopsy compatible to CD and response to a gluten-free diet.
CONCLUSIONS:
Organ-specific diseases were observed solely in JSLE patients and required specific therapy. The presence of these antibodies recommends the evaluation of organ-specific diseases and a rigorous follow-up.

PMID: 22261392 [PubMed]

Received: 19/03/2011 - Accepted : 13/06/2011 - In Press: 07/03/2012 - Published: 07/03/2012

Top of the Page

Web sites for on line Journals
© Clinical and Experimental Rheumatology (Journal with On line Submission) ISSN n 1593-098X
- VAT IT-00783170509