Lack of association between CTLA-4 +49A/G and -318C/T polymorphisms and Behçet`s disease risk: a meta-analysis

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Rheumatology ArticleY. Zhang, W. Xu, Z. Duan, S. Liu, H. Pan, D. Ye

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China.

CER5591 Submission on line 2012 Vol.30, N°3 ,Suppl.72 - PI 0046, PF 0050
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To more precisely determine whether there is a significant association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the susceptibility for Behçet`s disease.
Eight studies that included data from 7 articles were identified using PubMed, Embase, Chinese Biomedical Literature Database (CBM), and Chinese National Knowledge Infrastructure (CNKI) published before March 2012. Meta-analysis was performed for two CTLA-4 gene polymorphisms, +49A/G (rs231775) and -318C/T (rs5742909). Statistical analyses were performed using software Review Manager (version 5.1) and Stata (version 11.0). The pooled odds ratio (OR) with 95% confidence interval (95%CI) were presented.
Overall, no significant association was detected in all genetic models when all studies were pooled into the meta-analysis (for +49A/G polymorphism: A vs. G, OR=1.173, 95% CI=0.790–1.743; A/A vs. A/G+G/G, OR=1.422, 95% CI=0.718–2.814; A/A+A/G vs. G/G, OR=1.421, 95% CI=0.729–2.767; and for -318C/T polymorphism: C vs. T, OR=1.051, 95% CI=0.844–1.307; C/C vs. T/T+C/T, OR=1.154 95% CI=0.891–1.495, C/C+C/T vs. T/T, OR=1.044, 95% CI=0.301–3.617). Furthermore, in the subgroup analysis by ethnicity, there was also lack of evidence for the association in Turkish patients.
Our study failed to provide evidence for the genetic association between CTLA-4 +49A/G and -318C/T polymorphisms with Behçet`s disease based on currently available evidence from literature. Further confirmations in large and well-designed studies including other CTLA-4 gene polymorphisms are needed.

PMID: 23010350 [PubMed]

Received: 29/03/2012 - Accepted : 05/09/2012 - In Press: 25/09/2012 - Published: 19/11/2012