Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China.
To more precisely determine whether there is a significant association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the susceptibility for Behçet`s disease.
Eight studies that included data from 7 articles were identified using PubMed, Embase, Chinese Biomedical Literature Database (CBM), and Chinese National Knowledge Infrastructure (CNKI) published before March 2012. Meta-analysis was performed for two CTLA-4 gene polymorphisms, +49A/G (rs231775) and -318C/T (rs5742909). Statistical analyses were performed using software Review Manager (version 5.1) and Stata (version 11.0). The pooled odds ratio (OR) with 95% confidence interval (95%CI) were presented.
Overall, no significant association was detected in all genetic models when all studies were pooled into the meta-analysis (for +49A/G polymorphism: A vs. G, OR=1.173, 95% CI=0.7901.743; A/A vs. A/G+G/G, OR=1.422, 95% CI=0.7182.814; A/A+A/G vs. G/G, OR=1.421, 95% CI=0.7292.767; and for -318C/T polymorphism: C vs. T, OR=1.051, 95% CI=0.8441.307; C/C vs. T/T+C/T, OR=1.154 95% CI=0.8911.495, C/C+C/T vs. T/T, OR=1.044, 95% CI=0.3013.617). Furthermore, in the subgroup analysis by ethnicity, there was also lack of evidence for the association in Turkish patients.
Our study failed to provide evidence for the genetic association between CTLA-4 +49A/G and -318C/T polymorphisms with Behçet`s disease based on currently available evidence from literature. Further confirmations in large and well-designed studies including other CTLA-4 gene polymorphisms are needed.
PMID: 23010350 [PubMed]
Received: 29/03/2012 - Accepted : 05/09/2012 - In Press: 25/09/2012 - Published: 19/11/2012