23 August 2014
 

Gout: thoughts about a treat-to-target programme

Rheumatology ArticleJ. Braun, J. Smolen

Rheumazentrum Ruhrgebiet, Herne, Germany. j.braun@rheumazentrum-ruhrgebiet.de

CER5999 Submission on line
D. Specific diseases

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Abstract

Gout is a rheumatic disease resulting from deposition of uric acid crystals in tissues and fluids within the body. The pathogenesis involves underexcretion or overproduction of uric acid, a biproduct of metabolism of purines, resulting in a metabolic disorder commonly known as hyperuricaemia, has a relatively high prevalence in the population (0.51%, similar to rheumatoid arthritis). Patients with hyperuricaemia are at risk to develop acute gouty attacks which may be severely painful. The attacks tend to occur episodically over a few days up to a week or two, but gout may later become chronic. Different aims of therapy and management are well suited as targets of treatment, including reduction of purine intake, increased of excretion of uric acid, mobilisation of urate pools within the body, and reduction of acute and chronic inflammation through anti-inflammatory medications.

PMID: 23079069 [PubMed]

Received: 14/09/2012 - Accepted : 19/09/2012 - In Press: 18/10/2012 - Published: 20/11/2012

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