New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children

Purchase this article

Rheumatology ArticleS. Gaspari, M. Marsili, M. Imazio, A. Brucato, C. Di Blasi Lo Cuccio, F. Chiarelli, L. Breda

Department of Pediatrics, University of Chieti, Chieti, Italy. gasparistefania@libero.it

CER6257 Submission on line 2013 Vol.31, N°5 - PI 0788, PF 0794


Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15–30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflammatory pathways have been proposed as mechanisms involved in recurrences. Therapeutic strategies are not standardised, non-steroidal anti-inflammatory drugs at high dosages being the mainstay of therapy with the possible addition of low dose colchicine to prevent recurrences. Biological agents are considered a possible new therapeutic frontiers in the care of idiopathic recurrent pericarditis.

PMID: 23981280 [PubMed]

Received: 10/01/2013 - Accepted : 03/04/2013 - In Press: 02/08/2013 - Published: 19/09/2013