abs1802

Dupuytren's disease in type I diabetic subjects: Investigation of biochemical markers of type III and I collagen

P.E.T. Arkkila¹, P.J. Koskinen³, I.M. Kantola², T. Rönnemaa², E. Seppäne⁴, J.S. Viikari²

¹Department of Medicine, Helsinki University Central Hospital; ²Department of Medicine, Turku University Central Hospital; ³Central Laboratory, Turku University Central Hospital; ⁴Department of Statistics, University of Turku, Finland.

ABSTRACT
Objective
To clarify whether biochemical markers of collagen type III and I metabolism show alterations in type I diabetic subjects with Dupuytren's disease (DD) compared to those without DD.

Methods
DD was assessed in a total of 28 type I diabetic subjects, mean age 43.4 ± 9.5 (SD) and duration of diabetes 25.2 ± 9.7 years. Concentrations of aminoterminal propeptide of type III procollagen (PIIINP), carboxyterminal propeptide of type I procollagen (PICP) and carboxyterminal cross-linked telopeptide of type I collagen (ICTP) in serum and excretion of cross-linked N-telopeptides of type I collagen (NTX) and deoxypyridinoline crosslinks (DPyr) into urine were measured.

Results
The prevalence of DD was 32% (9 of 28 diabetic subjects). Average serum ICTP was 2.7 ± 0.8 mg/l in subjects without DD and 3.6 ± 1.2 mg/l with DD (p = 0.0276). No significant association between other collagen markers and DD was found. The reference intervals of PIIINP and ICTP were exceeded only in 1 and 2 subjects, respectively, and they both had DD.

Conclusion
The degradation of type I collagen might be increased in diabetic subjects with DD. The overall implication was that synthesis or degradation of type III and I collagen in diabetic subjects with DD did not differ enough from those without DD to reflect changes in the biochemical markers of type III and I collagen.

Key words
Dupuytren's disease, carboxyterminal cross-linked telopeptide of type I collagen, carboxyterminal propeptide of type I procollagen, aminoterminal propeptide of type III procollagen, cross-linked N-telopeptides of type I collagen, deoxypyridinoline crosslinks of type I collagen.

This study was financially supported by grants from the Turku University Foundation, The Finnish Medical Foundation and Science Foundation of Orion.

Please address correspondence and reprint requests to: Perttu E.T. Arkkila, MD, Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.
E-mail: perttu.arkkila@hus.fi