Catastrophic antiphospholipid syndrome associated with crescentic glomerulonephritis: A clinicopathologic case

M. Cisternas¹, M.A. Gutiérrez¹, H. Rosenberg², A. Jara³, S. Jacobelli¹

Departments of ¹Clinical Immunology and Rheumatology, ²Pathology, and ³Nephrology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

ABSTRACT
The association of renal failure with catastrophic antiphospholipid syndrome has been reported in the context of microvascular occlusions and/or malignant hypertension. We describe a 36-year-old woman who died of multiorgan failure with the laboratory, clinical and histopathological characteristics of catastrophic antiphospholipid syndrome associated with a crescentic glomerulonephritis and renal failure.

Key words
Catastrophic antiphospholipid syndrome, antiphospholipid syndrome, crescentic glomerulonephritis, antiphospholipid antibodies, renal failure.

Supported by Fondecyt grant no. 1980954.

Please address correspondence and reprint requests to: Dr. Miguel A. Gutiérrez, Depto. Inmunología Clínica y Reumatología, Pontificia Universidad Católica de Chile, Marcoleta 367-Casilla 114-D-, Santiago, Chile.
E-mail: gutierre@med.puc.cl

Clini Exp Rheumatol 2000; 18: 252-254.
© Copyright Clinical and Experimental Rheumatology 2000.