Signal transduction in T lymphocytes

E.J. Peterson, G.A. Koretzky

Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.


Abstract
T lymphocytes utilize a variety of surface receptors to transmit environmental signals across the plasma membrane and initiate biochemical events leading to responses such as proliferation, anergy, cytokine secretion, and death. The T cell receptor complex, CD28, IL-2 receptor, and CD95 each couple to distinct sets of cytoplasmic signaling events to modulate the biological responses of T cells. Deficiency or defective function of proteins involved in signaling through these receptors are associated with murine and human disease.

Key words
T cell receptor (TCR), signal transduction, CD95, CD28, IL-2 receptor.

Erik J. Peterson, MD and Gary A. Koretzky, MD, PhD.

Please address correspondence and reprint requests to: Erik J. Peterson, 540 EMRB, University of Iowa, Iowa City, IA 52242, USA.

Received on July 13, 1998; accepted on July 20, 1998.

Clin Exp Rheumatol 1999; 17: 107-114.
© Copyright Clinical and Experimental Rheumatology 1999.