Combination cyclosporine and (hydroxy)chloroquine in rheumatoid arthriti

B.A.C. Dijkmans¹, R.B.M. Landewé², B.E.E.M. van den Borne³, F.C. Breedveld⁴

¹Prof.dr. Ben A.C. Dijkmans, MD, PhD, Rheumatology Department, Academic Hospital Vrije Universiteit, Amsterdam; ²R.B.M. Landewé, MD, Rheumatology Department, Atrium Medical Center, Heerlen; ³B.E.E.M. van den Borne, MD, Rheumatology Department, Catharina Hospital, Eindhoven; ⁴Ferdinand C. Breedveld, MD, Professor, Rheumatology Department, Leiden University Medical Center, Leiden, The Netherlands.

ABSTRACT
Antimalarials are attractive candidates for combination therapy. In vitro experiments have revealed a synergistic mode of action of cyclosporine and chloroquine which could not, however, be confirmed in a clinical trial.

Key words
Cyclosporine, anti-malarials, chloroquine, rheumatoid arthritis.

Please address correspondence and reprint requests to: Prof.dr. Ben A.C. Dijkmans, Academic Hospital Vrije Universiteit, Rheumatology Department - B 417, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Email: secr.reumatology@azvu.nl

Clin Exp Rheumatol 1999; 17 (Suppl. 18): S103 - S104.
© Copyright Clinical and Experimental Rheumatology 1999.