Dual positivity for cytoplasmic and perinuclear antineutrophil antibodies in a patient with Henoch-Schönlein purpura 

I. Ferraz-Amaro, M.J. Herrero1, A. Jurado1, F. Díaz-González

Servicio de Reumatología and 1Sección de Inmunología, Hospital Universitario de Canarias, Tenerife, Spain.

ABSTRACT
We herein describe the case of a 60-year-old man who presented clinical and histopathological evidence of Henoch-Schönlein purpura. Antineutrophil antibodies (ANCA) showed positive results on an enzyme-linked immunosorbent assay and immunofluorescence for anti-myeloperoxidase and anti-proteinase 3 antibodies. Dual positivity for both cytoplasmatic (C-ANCA) and perinuclear (P-ANCA) antineutrophil antibodies has been found previously in a small number of reports, but to our knowledge this is the first time the simultaneous presence of C-ANCA and P-ANCA has been observed in Henoch-Schšnlein purpura.

Key words
Henoch-Schönlein purpura, anti-neutrophil antibodies.

Please address correspondence and reprint requests to: Dr. Iván Ferraz-Amaro,  Servicio de Reumatología, Hospital Universitario de Canarias, Ofra s/n. La Cuesta, 38320 Santa Cruz de Tenerife, Spain. E-mail: iferraz@comtf.es

Clin Exp Rheumatol 2004; 22: 233-234.
© Copyright Clinical and Experimental Rheumatology 2004.