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Do vaccinations affect the clinical course of systemic necrotising vasculitis? A prospective observational web-based study

1, 2, 3, 4, 5, 6, 7, 8

 

  1. Univ. Paris-Descartes, Sorbonne Paris Cité, Médecine; Assistance Publique-Hôpitaux de Paris, Dept. of Infectious Diseases, Hôpital Cochin; Inserm CIC 1417; Sorbonne Univ., UPMC Univ. Paris 06, Inst.Pierre-Louis d’Épidémiologie-Santé Publ., Paris, France.
  2. Sorbonne Universités, UPMC Université Paris 06, INSERM, Institut Pierre-Louis d’Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
  3. Dept. of Medicine, Div. of Rheumatology, Mount Sinai Hospital, Univ. of Toronto, Canada; and Assistance Publique–Hôpitaux de Paris, Dept.of Internal Medicine, Centre de Référence Maladies Rares-Vascularités et Sclérodermie, Hôpital Cochin, Paris, France.
  4. Université Paris-Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris; and Assistance Publique–Hôpitaux de Paris, Department of Infectious Diseases, CIC Cochin Pasteur, Hôpital Cochin, Paris; and Inserm CIC 1417, Paris, France.
  5. Assistance Publique–Hôpitaux de Paris, Department of Internal Medicine, Hôpital Saint-Louis, Paris, France.
  6. Assistance Publique–Hôpitaux de Paris, Department of Internal Medicine, Centre de Référence Maladies Rares-Vascularités et Sclérodermie, Hôpital Cochin, Paris, France.
  7. Sorbonne Universités, UPMC Université Paris 06, INSERM, Institut Pierre-Louis d’Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
  8. Sorbonne Univ., UPMC Univ. Paris 06, Inst. Pierre-Louis d’Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris; Univ. Versailles Saint-Quentin-en-Yvelines; Hôp. de Paris, Dept.of Int. Medicine, Hôp. Ambroise-Paré, Boulogne-Billancourt, France.

CER9106
2016 Vol.34, N°3 ,Suppl.97
PI 0089, PF 0092
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PMID: 27214210 [PubMed]

Received: 10/11/2015
Accepted : 25/01/2016
In Press: 19/05/2016
Published: 27/05/2016

Abstract

OBJECTIVES:
To estimate the impact of vaccinations, infections and traumatic life events on the disease activity of a web-based cohort of systemic necrotising vasculitis (SNV) patients.
METHODS:
Adults diagnosed with SNV self-reported vaccinations, infectious episodes and traumatic life events every 3 months during follow-up on a secure dedicated website. Participants reported information on disease activity assessed with 3 scores: the French version of the Medical Outcome Study Short Form-36 (SF-36), the visual numerical scale for Patient Global Assessment (PGA) and the modified Disease Extent Index (mDEI).
RESULTS:
Between December 2005 and October 2008, 145 participants (mean ± SD age 53±13 years; 57% males) were included. Mean follow-up was 445±325 days. SNVs were distributed as follows: 46% granulomatosis with polyangiitis (Wegener’s), 22% eosinophilic granulomatosis with polyangiitis (Churg-Strauss), 18% polyarteritis nodosa and 8% microscopic polyangiitis. During follow-up, 94 vaccinations, 57 acute infectious episodes and 274 traumatic life events were reported. In univariate and multivariate analyses, only traumatic life events were significantly associated with decreased SF-36 mental and physical component scores. No significant SF-36, PGA and mDEI scores variations were reported during the 3 months following acute infectious episode or vaccine administration.
CONCLUSIONS:
No significant clinical impact of vaccinations on SNV activity was found in this prospective observational study.

Rheumatology Article