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Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis


1, 2, 3, 4, 5, 6, 7

 

  1. Rheumatology Research Group, University of Birmingham, UK.
  2. Histopathology Department, Imperial College Hospitals NHS Trust, London, UK.
  3. Rheumatology Research Group, University of Birmingham, UK.
  4. School of Physics, University of Exeter, UK.
  5. Glasgow Biomedical Research Centre, University of Glasgow, UK.
  6. Rheumatology Research Group, University of Birmingham, UK.
  7. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK. peter.taylor@kennedy.ox.ac.uk

CER9346
2016 Vol.34, N°6
PI 1072, PF 1076
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PMID: 27749236 [PubMed]

Received: 15/02/2016
Accepted : 30/05/2016
In Press: 08/09/2016
Published: 28/11/2016

Abstract

OBJECTIVES:
An important feature of rheumatoid arthritis (RA) is hypoxia-driven synovial angiogenesis, but the relationship between change in vascularity, as measured by power Doppler ultrasound (PDUS), and oxygen tensions is unaddressed.
METHODS:
Metacarpophalangeal (MCP) joint PDUS was assessed in 23 patients with RA, alongside arthroscopic synovitis and oxygen tension measurements, at baseline and 4 weeks after anti-tumour necrosis factor (TNF) inhibitors.
RESULTS:
Anti-TNF reduced PDUS scores, which were negatively correlated with rise in oxygen tensions. The latter was related to good EULAR response at week 52.
CONCLUSIONS:
Anti-TNF results in rapid reduction in synovial blood flow, with a corresponding rise in oxygen tension most marked in EULAR good responders.

Rheumatology Article