Clinical aspects
Changes in the pattern of death of 987 patients with systemic sclerosis from 1990 to 2009 from the nationwide Spanish Scleroderma Registry (RESCLE)
M. Rubio-Rivas1, C.P. Simeón-Aznar2, C. Velasco3, B. Marí-Alfonso4, G. Espinosa5, X. Corbella6, D. Colunga Argüelles7, M.V. Egurbide-Arberas8, N. Ortego-Centeno9, J.A. Vargas-Hitos10, M. Freire11, J.J. Ríos-Blanco12, L. Trapiella-Martínez13, M. Rodríguez-Carballeira14, V. Fonollosa-Pla15
- Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. mrubio@bellvitgehospital.cat
- Vall d’Hebron University Hospital, Department of Internal Medicine, Barcelona, Spain.
- Clinic Hospital, Department of Epidemiology Medicine, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
- Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona, Spain.
- Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatología, Hospital Clínic, Barcelona, Spain.
- Department of Internal Medicine, Bellvitge University Hospital-IDIBELL, L’Hospitalet de Llobregat, Barcelona, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.
- Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain.
- Department of Internal Medicine, Hospital Universitario Cruces, Barakaldo, Spain.
- Department of Internal Medicine, Hospital Universitario San Cecilio, Granada, Spain.
- Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain.
- Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Spain.
- Department of Internal Medicine, Hospital La Paz, Madrid, Spain.
- Department of Internal Medicine, Hospital de Cabueñes, Gijón, Spain.
- Department of Internal Medicine, Hospital Universitari Mutua de Terrassa, Barcelona, Spain.
- Vall d’Hebron University Hospital, Department of Internal Medicine, Barcelona, Spain.
on behalf of RESCLE investigators, Autoimmune Diseases Study Group (GEAS)
CER9503
2017 Vol.35, N°4 ,Suppl.106
PI 0040, PF 0047
Clinical aspects
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PMID: 28229826 [PubMed]
Received: 14/04/2016
Accepted : 07/11/2016
In Press: 06/02/2017
Published: 12/10/2017
Abstract
OBJECTIVES:
To determine the changes in the pattern of death of patients with systemic sclerosis (SSc) throughout 20 years.
METHODS:
Data were collected from the Spanish Scleroderma Registry (RESCLE), retrospective multicentre database from 1990 to 2009. SSc-related and SSc-non related causes of death were assessed.
RESULTS:
987 patients were recruited. Overall standardised mortality ratio (SMR) was 2.34 (2.24-2.44). SSc-related causes of death were responsible of 72% of all deaths of those patients diagnosed within 1990-99 vs. 48% within 2000-09 (p=0.006). Relative pulmonary death rate was stable over time (68.1% within 1990-99 vs. 63.9% within 2000-09, p=0.815). Relative renal death rate was decreasing over time (17% within 1990-99 vs. 5.5% within 2000-09, p=0.175). Heart distribution tripled its ratio (12.8% within 1990-99 vs. 30.6% within 2000-09, p=0.058).
CONCLUSIONS:
SSc-related causes of death were decreasing over time and, among them, pulmonary involvement was the leading cause of death in both decades. The ratio of renal causes decreased since 1990 at the time that the ratio of cardiac causes increased.
