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Current surgical approaches in Takayasu's arteritis: a single centre experience

1, 2, 3, 4, 5, 6, 7, 8, 9

  1. Department of Cardiovascular Surgery, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey. canerkvc@yahoo.com
  2. Department of Cardiovascular Surgery, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
  3. Department of Cardiovascular Surgery, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
  4. Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
  5. Department of Cardiovascular Surgery, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
  6. Department of Cardiovascular Surgery, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
  7. Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
  8. Department of Cardiovascular Surgery, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
  9. Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, University of Istanbul-Cerrahpasa, Istanbul, Turkey.

CER9591 Submission on line
Full Papers

Rheumatology Article

 

Abstract

OBJECTIVES:
We investigated cardiovascular surgical interventions in a group of patients with Takayasu’s arteritis (TAK) diagnosed and followed by a single centre.
METHODS:
Twenty patients with TAK (5 males, 15 females, mean current age: 38.1±10.7) who were operated for a broad spectrum of cardiovascular diseases ranging from coronary heart disease to ceoliac stenosis or aneurysm between July 2008 and April 2016 were studied. One patient underwent operation related to aneurysm of ascending aorta and aortic insufficiency, 2 patients had operations for both coronary arteries originating from aortic arch, 6 patients for only arteries originating from aortic arch, 1 patient for both carotid and infra-inguinal artery, 5 patients for aorta-iliac or femoral revascularisation, 5 patients for renal artery and/or coeliac or superior mesenteric artery revascularisations. Three of these interventions were endarterectomy and patch plasty.
RESULTS:
The mean time between diagnosis and surgical intervention was 6.1±3.1 years (range: 3 months-12 years). A total of 4/32 (12.5%) grafts were occluded during the follow up period of mean 39.2±24.6 months. Secondary interventions like cross-femoral, or graft to superficial femoral artery bypasses were needed in 2 patients who underwent aorta-bifemoral bypasses to keep patency. There was no operative mortality. We did not observe any anastomotic aneurysm. One patient died due to graft infection 3 months after the operation. Stroke occurred in 2 patients who underwent revascularisations of the arteries originating from aortic arch.
CONCLUSIONS:
In our series, we have a relatively good midterm patency rates in patients with TAK and did not observe any anastomotic pseudoaneurysm. Stroke developed in 2 patients and mortality occurred in one patient due to the graft infection 3 months after the operation. In patients with limited carotid or aorta-iliac stenosis, chance for endarterectomy should be evaluated. Well-controlled disease activity with intensive medical treatment and multi-disciplinary approach could be associated with a favourable long-term outcome.

PMID: 31376252 [PubMed]

Received: 17/05/2016 - Accepted : 08/07/2019 - In Press: 03/08/2019