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Remarkable damage along with poor quality of life in Takayasu arteritis: cross-sectional results of a long-term followed-up multicentre cohort


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17

 

  1. Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Turkey.
  2. Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Turkey. burakerer@yahoo.com
  3. Division of Rheumatology, Department of Internal Medicine, Hacettepe University, Medical Faculty, Ankara, Turkey.
  4. Division of Rheumatology, Department of Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey.
  5. Division of Rheumatology, Department of Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey.
  6. Division of Rheumatology, Department of Internal Medicine, Cukurova University, Medical Faculty, Adana, Turkey.
  7. Division of Rheumatology, Department of Internal Medicine, Ege University, School of Medicine, Izmir, Turkey.
  8. Division of Rheumatology, Dept. of Internal Medicine, Gaziantep University, Gaziantep Medical Faculty, Gaziantep, Turkey.
  9. Division of Rheumatology, Department of Internal Medicine, Hacettepe University, Medical Faculty, Ankara, Turkey.
  10. Division of Rheumatology, Department of Internal Medicine, Marmara University, School of Medicine, Istanbul, Turkey.
  11. Division of Rheumatology, Department of Internal Medicine, Cukurova University, Medical Faculty, Adana, Turkey.
  12. Division of Rheumatology, Department of Internal Medicine, Ege University, School of Medicine, Izmir, Turkey.
  13. Division of Rheumatology, Dept. of Internal Medicine, Gaziantep University, Gaziantep Medical Faculty, Gaziantep, Turkey.
  14. Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Turkey.
  15. Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Turkey.
  16. Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Turkey.
  17. Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Turkey.

CER9578
2017 Vol.35, N°1 ,Suppl.103
PI 0077, PF 0082
Clinical aspects

purchase article

PMID: 27908308 [PubMed]

Received: 13/05/2016
Accepted : 29/07/2016
In Press: 10/11/2016
Published: 19/04/2017

Abstract

OBJECTIVES:
We aimed to assess the outcome of a large Takayasu arteritis (TAK) cohort using the vasculitis damage index (VDI) and quality of life (QoL) scale, tools which have been validated for vasculitis.
METHODS:
Disease activity, damage and QoL were cross-sectionally evaluated in 165 TAK patients from 6 centres. SF-36 were applied to 51 age-matched healthy controls (HC). Persistent activity for ≥6 months was considered as treatment resistance (r-TAK). The correlation between VDI, clinical characteristics and mental (MCS)/physical (PCS) component scores of SF-36 were analysed. SF-36 and VDI scores were compared between TAK subgroups and HC.
RESULTS:
The median age, follow-up time and disease duration were 40 (17-68), 60 (6-384), and 72 (6-396) months, respectively. 35% of them were r-TAK. VDI scores (VDIs) in TAK 4 (1-12) were mainly due to the disease itself [4 (1–10)]. VDIs in r-TAK were significantly higher than nr-TAK [5 (2-12) vs. 3 (2-10), p<0.001)]. In the TAK patients, MCS and PCS were found as 43±10 and 38±11, respectively. A high proportion of poor MCS (70%) and PCS (80%) were demonstrated in TAK. A significantly negative but weak correlation was observed between VDI and MCS (p=0.003, r=-0.23), PCS (p<0.001, r=-0.34). Higher VDIs were detected in patients with PCS <50 [5 (1-12) vs. 2 (1-6) p<0.001)]. SF-36 score was significantly lower in TAK than HC.
CONCLUSIONS:
Disease-related damage mainly caused by peripheral vascular involvement was more predominant than treatment-related damage without reaching the level of severe damage scores, but contributing to poor QoL, in the TAK cohort.

Rheumatology Article