Review
Do MicroRNAs have a key epigenetic role in osteoarthritis and in mechanotransduction?
A. De Palma1, S. Cheleschi2, N.A. Pascarelli3, S. Tenti4, M. Galeazzi5, A. Fioravanti6
- Department of Medicine, Surgery and Neurosciences, University of Siena; and Department of Medical Biotechnologies, University of Siena, Italy. annadepalma90@live.it
- Department of Medicine, Surgery and Neurosciences, University of Siena; and Department of Medical Biotechnologies, University of Siena, Italy.
- Rheumatology Unit, Azienda Ospedaliera Universitaria Senese, Policlinico “Le Scotte”, University of Siena, Italy.
- Department of Medicine, Surgery and Neurosciences, University of Siena, Italy.
- Department of Medicine, Surgery and Neurosciences, University of Siena, Italy.
- Rheumatology Unit, Azienda Ospedaliera Universitaria Senese, Policlinico “Le Scotte”, University of Siena, Italy.
CER9598
2017 Vol.35, N°3
PI 0518, PF 0526
Review
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PMID: 28079507 [PubMed]
Received: 23/05/2016
Accepted : 29/09/2016
In Press: 04/01/2017
Published: 07/06/2017
Abstract
Osteoarthritis (OA) is the most common degenerative disease affecting joint tissues. The pathogenesis of OA is complex and poorly understood, as well as the multiple factors contributing to its development and progression. Accumulating evidence has suggested that microRNAs (miRNAs) play an important role as regulators of cartilage biology and in the pathogenesis of OA. It has been demonstrated that mechanical loading, important for the regulation of cartilage metabolism, affects miRNAs expression. Furthermore, miRNAs present in human plasma and in synovial fluid could represent promising biological markers for OA. Herein, we have reviewed the current state of research on miRNAs in cartilage homeostasis and OA pathogenesis and their potential clinical applications.
