Pathogenesis
Regulatory roles of B cells in infectious diseases
S. Fillatreau1
- Inst.Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris; Univ.Paris Descartes, Sorbonne Paris Cité; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôp.Necker Enfants Malades, Paris, France; Deutsches Rheuma-Forschungszentrum, Berlin, Germany
CER9696
2016 Vol.34, N°4 ,Suppl.98
PI 0001, PF 0005
Pathogenesis
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PMID: 27586794 [PubMed]
Received: 28/06/2016
Accepted : 29/06/2016
In Press: 20/07/2016
Published: 03/08/2016
Abstract
B lymphocytes provide essential mechanisms of protection against infectious diseases. The secretion of specific antibodies by long-lived plasma cells is thought to account for the improved resistance afforded by most successful vaccines against pathogens. Accordingly, a goal in vaccine development is to induce potent B cell responses in order to drive the efficient formation of long-lived antibody-secreting cells. However, the roles of activated B cells are complex in infectious diseases. It was recently observed that activated B cells could also negatively regulate host defence mechanisms, both during primary infection and, after vaccination, upon secondary challenge, via mechanisms involving their production of the anti-inflammatory cytokines interleukin (IL)-10 and IL-35. Remarkably, the B cells expressing IL-10 and IL-35 in vivo were distinct subsets of IgMhiCD19+CD138hi antibody-secreting cells. A better understanding of the diverse roles of these distinct antibody-secreting cell subsets in immunity and immunological memory, as well as of the signals controlling their generation, might help the rational development of better prophylactic and therapeutic vaccines.
