Pathogenesis
Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation
J. Hahn1, J. Knopf2, C. Maueröder3, D. Kienhöfer4, M. Leppkes5, M. Herrmann6
- Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.
- Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.
- Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.
- Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.
- Department of Internal Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany.
- Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany. martin.herrmann@uk-erlangen.de
CER9726
2016 Vol.34, N°4 ,Suppl.98
PI 0006, PF 0008
Pathogenesis
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PMID: 27586795 [PubMed]
Received: 04/07/2016
Accepted : 04/07/2016
In Press: 29/07/2016
Published: 03/08/2016
Abstract
Neutrophils, the most abundant leukocytes in the human body, are considered to be the first line of defense in the fight against microorganisms. In this fight neutrophils employ weaponry such as reactive oxygen species produced via the NADPH oxidase complex 2 together with the release of intracellular granules containing antimicrobial agents. The discovery that activated neutrophils release decondensed chromatin as DNase-sensitive neutrophil extracellular traps (NETs) lead to a renewed interest in these leukocytes and the function of NETs in vivo. In this review, we will focus on desirable as well as detrimental features of NETs by the example of gout and pancreatitis. In our models we observed that neutrophils drive the initiation of inflammation and are required for the resolution of inflammation.
