impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Case Reports

 

Critical role of STIR MRI in early detection of post-streptococcal periostitis with dysproteinaemia (Goldbloom’s syndrome)

1, 2, 3, 4, 5, 6, 7, 8

 

  1. 2nd Department of Paediatrics, Giannina Gaslini Institute, and University of Genova, Italy. papariccardo86@gmail.com
  2. 2nd Department of Paediatrics, Giannina Gaslini Institute, Genova, Italy.
  3. 2nd Department of Paediatrics, Giannina Gaslini Institute, Genova, Italy.
  4. 2nd Department of Paediatrics, Giannina Gaslini Institute, Genova, Italy.
  5. Service of Radiology, Giannina Gaslini Institute, Genova, Italy.
  6. 2nd Department of Paediatrics, Giannina Gaslini Institute, Genova, Italy.
  7. 2nd Department of Paediatrics, Giannina Gaslini Institute, and University of Genova, Italy.
  8. 2nd Department of Paediatrics, Giannina Gaslini Institute, Genova, Italy.

CER9895
2017 Vol.35, N°3
PI 0516, PF 0517
Case Reports

Free to view
(click on article PDF icon to read the article)

PMID: 28339360 [PubMed]

Received: 03/09/2016
Accepted : 20/01/2017
In Press: 23/03/2017
Published: 07/06/2017

Abstract

OBJECTIVES:
In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English.
METHODS:
We report two further cases of Goldbloom’s syndrome with a review of the literature in English.
RESULTS:
Our two patients lived in the same Italian region and presented their syndrome onset a week apart. Early use of STIR MRI revealed an atypical metaphyseal hyperintensity in the femurs and tibias. X-ray showed periosteal hyperostosis. A short cycle of corticosteroids led to rapid recovery of symptoms and disappearance of bone changes.
CONCLUSIONS:
The reported cases highlight a likely under-recognised post-streptococcal inflammatory periosteal reaction and emphasise the diagnostic utility of the newer imaging modalities.

Rheumatology Article