impact factor, citescore
logo
 

Review

 

An update on the animal models in hyperuricaemia research


1, 2, 3

 

  1. Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China. 463905719@qq.com
  2. Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  3. Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

CER10063
2017 Vol.35, N°5
PI 0860, PF 0864
Review

Free to view
(click on article PDF icon to read the article)

PMID: 28516889 [PubMed]

Received: 02/11/2016
Accepted : 10/03/2017
In Press: 08/05/2017
Published: 15/09/2017

Abstract

Hyperuricaemia is a metabolic disease caused by purine metabolic abnormalities, mainly due to the increased formation or reduced excretion of uric acid. In recent years, it has been proved that hyperuricaemia is an important risk factor for chronic kidney disease (CKD) and cardiovascular disease, and it also takes part in the pathophysiology of metabolic syndrome. In addition, more attention has been concentrated on the pathogenesis or treatment of hyperuricaemia. Since establishing an animal model on hyperuricaemia is the foundation for further researches, several methods to establish the hyperuricaemia model have been developed. In this article, remarkable progress on the modelling approach are summarised, and a comparison study on different methods of developing hyperuricaemia animal models was conducted.

Rheumatology Article