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The prevalence and clinical effect of immunogenicity of TNF-α blockers in patients with axial spondyloarthritis


1, 2, 3, 4, 5, 6

 

  1. The Talpiot Medical Leadership Program, and Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel. gilbor16@gmail.com
  2. Rheumatology Unit, The Chaim Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  3. Rheumatology Unit, The Chaim Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  4. Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  5. Department of Internal Medicine F, The Chaim Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  6. Department of Internal Medicine F, The Chaim Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.

CER10438
2018 Vol.36, N°2
PI 0228, PF 0232
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PMID: 29185966 [PubMed]

Received: 23/03/2017
Accepted : 26/06/2017
In Press: 28/11/2017
Published: 18/04/2018

Abstract

OBJECTIVES:
To evaluate the prevalence of immunogenicity of TNF-α blockers in axial spondyloarthritis (SpA) patients and to assess the effect of immunogenicity on drug levels and clinical response. METHPDS: Patients with axial SpA treated with either infliximab (INF), adalimumab (ADA) or etanercept (ETN) were recruited to our observational cross-sectional study. Demographic and clinical data were collected and disease activity scores were assessed. Drug trough levels and anti-drug antibodies were measured in serum samples and collected before the next administration.
RESULTS:
Thirty-nine patients with axial SpA with a mean age of 46.3±12.7 (10 women) were recruited to the study (14 receiving INF, 16 ADA and 9 ETN). Patients’ mean therapy duration was 50.6 months (±46.4) and 6 (15%) of them were using MTX concomitantly with the TNF-α blockers. Anti-drug antibodies were found in 6 (15%) patients (4 with INF and 2 with ADA), all of which had undetectable drug level. No anti-drug antibodies were detected in patients treated with ETN. Immunogenicity was associated with higher BASDAI (Bath Ankylosing Spondylitis Disease Index), ASDAS-CRP (Ankylosing Spondylitis Disease Activity Score) and ASDAS-ESR.
CONCLUSIONS:
Axial SpA patients failure to respond to TNF-α blockers may be at least partially related to immunogenicity. Measurement of anti-drug antibodies and drug levels in these patients may assist in determining further treatment strategies.

Rheumatology Article