Case Report
Successful use of rituximab in granulomatosis with polyangiitis with aortic inflammation
L. Pineda Bernal1, N. Bitencourt2, K. Batra3, E.B. Solow4
- Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, USA. lucaspinedabernal26@hotmail.com
- Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, USA.
- Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
- Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, USA.
CER10770
2019 Vol.37, N°2 ,Suppl.117
PI 0144, PF 0147
Case Report
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PMID: 30299239 [PubMed]
Received: 01/09/2017
Accepted : 09/01/2018
In Press: 20/09/2018
Published: 21/05/2019
Abstract
Large-vessel inflammation, although rare, has been increasingly recognised as a complication of granulomatosis with polyangiitis (GPA) in recent years. The presentation is highly variable, ranging from an incidental finding to aortic dissection and rupture. Treatment has predominately consisted of a combination of cyclophosphamide and high dose corticosteroids with surgical intervention when indicated. We present the case of a 34-year-old male diagnosed with GPA after presenting with sinus and eye inflammation and the ensuing investigation revealed large vessel involvement that remarkably improved after 6 months of treatment with the combination of rituximab infusions, methotrexate and corticosteroids.
