impact factor
logo
 

Case Report

 

Successful use of rituximab in granulomatosis with polyangiitis with aortic inflammation


1, 2, 3, 4

 

  1. Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, USA. lucaspinedabernal26@hotmail.com
  2. Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, USA.
  3. Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
  4. Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, USA.

CER10770
2019 Vol.37, N°2 ,Suppl.117
PI 0144, PF 0147
Case Report

Free to view
(click on article PDF icon to read the article)

PMID: 30299239 [PubMed]

Received: 01/09/2017
Accepted : 09/01/2018
In Press: 20/09/2018
Published: 21/05/2019

Abstract

Large-vessel inflammation, although rare, has been increasingly recognised as a complication of granulomatosis with polyangiitis (GPA) in recent years. The presentation is highly variable, ranging from an incidental finding to aortic dissection and rupture. Treatment has predominately consisted of a combination of cyclophosphamide and high dose corticosteroids with surgical intervention when indicated. We present the case of a 34-year-old male diagnosed with GPA after presenting with sinus and eye inflammation and the ensuing investigation revealed large vessel involvement that remarkably improved after 6 months of treatment with the combination of rituximab infusions, methotrexate and corticosteroids.

Rheumatology Article