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Role of serum autoantibodies in blood brain barrier damages in neuropsychiatric systemic lupus erythematosus

1, 2, 3, 4, 5

 

  1. Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan. shunsei@med.kitasato-u.ac.jp
  2. Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan.
  3. Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan.
  4. Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan.
  5. Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

CER10814
2018 Vol.36, N°6
PI 1003, PF 1007
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PMID: 29846157 [PubMed]

Received: 15/09/2017
Accepted : 05/03/2018
In Press: 24/05/2018
Published: 06/12/2018

Abstract

OBJECTIVES:
The present study was carried out to elucidate the roles of serum autoantibodies in the development of blood-brain barrier (BBB) damages in neuropsychiatric systemic lupus erythematosus (NPSLE).
METHODS:
Paired serum and CSF samples were obtained from 101 SLE patients when they presented active neuropsychiatric manifestations (69 patients with diffuse psychiatric/neuropsychological syndromes [diffuse NPSLE] and 32 patients with neurologic syndromes or peripheral neuropathy [focal NPSLE]). IgG anti-NR2 subunit of NMDA receptor (anti-NR2), anti-Sm, anti-ribosomal P and IgG anti-cardiolipin in sera and albumin in CSF and sera were measured by ELISA. Blood-brain barrier (BBB) function was evaluated by Q albumin (CSF/serum albumin quotient x 1,000).
RESULTS:
Q albumin was significantly higher in acute confusional state (ACS) than in non-ACS diffuse NPSLE (anxiety disorder, cognitive dysfunction, mood disorder and psychosis) or in focal NPSLE. Anti-Sm, but not anti-NR2, anti-P or anticardiolipin, was significantly elevated in ACS compared with the other 2 groups of NPSLE, although serum anti-NR2 was significantly higher in ACS than that in focal NPSLE. Multiple regression analysis confirmed the significant contribution of anti-Sm (p=0.0040), but not anti-NR2 (p=0.5023), anti-P (p=0.2651), or anti-cardiolipin (p=0.6769) in the elevation of Q albumin.
CONCLUSIONS:
The data demonstrate that serum anti-Sm antibodies play a most important role in the disruption of BBB in NPSLE.

Rheumatology Article