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Peripheral CD4+CD28null T-cells as predictors of damage in systemic lupus erythematosus patients

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18

 

  1. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Científica del Sur, Lima, Perú. manuel_ugarte@yahoo.com
  2. Diagnostic Support Department, Hospital Grau, EsSalud, Lima, Perú.
  3. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  4. Molecular Biology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  5. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  6. Molecular Biology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  7. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  8. Molecular Biology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  9. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Científica del Sur, Lima, Perú.
  10. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  11. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  12. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  13. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  14. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  15. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Nacional Mayor de San Marcos, Lima, Perú.
  16. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Nacional Mayor de San Marcos, Lima, Perú.
  17. School of Medicine, University of Alabama at Birmingham, AL, USA.
  18. Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Nacional Mayor de San Marcos, Lima, Perú.

CER10850
2018 Vol.36, N°6
PI 1008, PF 1013
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PMID: 29745892 [PubMed]

Received: 28/09/2017
Accepted : 05/03/2018
In Press: 08/05/2018
Published: 06/12/2018

Abstract

OBJECTIVES:
To determine whether the CD4+CD28null T-cells subpopulation predicts the occurrence of damage in SLE.
METHODS:
This longitudinal study was conducted in consecutive SLE patients seen every six months in our Rheumatology Department since 2012. Patients in whom CD4+CD28null T-cells had been measured and who had at least one subsequent visit were included in the study. Survival analyses (univariable and multivariable Cox-regression models) were performed to determine the risk of overall and domain damage (as per the SLICC Damage Index - SDI) as a function of the frequency of this T-cell subpopulation. The multivariable model was adjusted for pertinent confounders. All analyses were performed using SPSS 21.0.
RESULTS:
One hundred and nineteen patients were evaluated; their mean (SD) age was 43.5 (11.9) years, 113 (95.0%) were female. Disease duration was 7.8 (7.0) years, the SLEDAI 5.3 (4.1) and the SDI 1.0 (1.4). The percentage of CD4+CD28null T-cells was 17.4 (14.0). The mean follow-up was 2.1 (0.8) years, and the mean number of visits per patient 3.5 (1.1). Forty-six (38.7%) patients increase at least one SDI point. In the univariable and multivariable analyses, the percentage of CD4+CD28null predicted the occurrence of lung damage [HR: 1.042 (CI95%: 1.001–1.085); p=0.047 and HR: 1.099 (CI95%1.020–1.184); p=0.013, respectively] but neither the total SDI score nor all other SDI domain scores were predicted by the percentage of CD4+CD28null cells.
CONCLUSIONS:
In SLE patients, CD4+CD28null T-cells predict the occurrence of new lung damage, independently of other risk factors but not of overall damage or damage on other domains.

Rheumatology Article