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Peripheral nervous system involvement in systemic lupus erythematosus: a review of the evidence

1, 2, 3, 4, 5

 

  1. Department of Medical Science, Section of Rheumatology, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Cona, Ferrara, Italy. brtlsn1@unife.it
  2. Department of Medical Science, Section of Rheumatology, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Cona, Ferrara, Italy.
  3. Department of Medical Science, Section of Rheumatology, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Cona, Ferrara, Italy.
  4. Rheumatology Unit, University Clinic and Azienda Ospedaliero-Universitaria of Cagliari, Italy.
  5. Department of Medical Science, Section of Rheumatology, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Cona, Ferrara, Italy.

CER10879
2019 Vol.37, N°1
PI 0146, PF 0155
Reviews

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PMID: 29846158 [PubMed]

Received: 09/10/2017
Accepted : 28/02/2018
In Press: 24/05/2018
Published: 18/01/2019

Abstract

In the past years the peripheral nervous system (PNS) involvement in systemic lupus erythematosus (SLE) has received little attention despite its potential significant impact. The true prevalence of PNS in SLE reported in studies is variable and strongly influenced by American College of Rheumatology (ACR) case definition that includes seven PNS manifestations (acute inflammatory demyelinating polyradiculoneuropathy, autonomic disorder, mononeuropathy, myasthenia gravis, cranial neuropathy, plexopathy and polyneuropathy). Other peripheral manifestations, such as chronic inflammatory demyelinating polyradiculoneuropathy and small fibre neuropathy, not included in the ACR nomenclature, have not been well characterised in SLE. The aim of this review is to focus on epidemiology, pathogenesis, diagnosis and clinical features of all possible different expressions of PNS involvement in SLE, with the final objective to profile the patient’s clinical characteristics.

Rheumatology Article