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Clinical aspects

 

The association of sociodemographic and disease variables with hand function: a Scleroderma Patient-centered Intervention Network cohort study

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11

 

  1. Behavioural Science Institute, Clinical Psychology, Radboud University, Nijmegen, the Netherlands; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal; Department of Psychiatry, McGill University, Montreal, Canada.
  2. Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
  3. Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
  4. Université Paris Descartes, Assistance Publique-Hopitaux de Paris; Service de Medicine Interne, Centre de Reference Maladies Systémiques Autoimmunes Rares, vascularites nécrosantes et sclérodermie systémique, Hopital Cochin, Paris, France.
  5. Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.
  6. Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal; Department of Medicine, McGill University, Montreal, Canada.
  7. Department of Rheumatology, Sint Maartenskliniek, the Netherlands.
  8. Leiden University Medical Center, Leiden; Haga Teaching Hospital, The Hague, the Netherlands.
  9. NVLE Dutch patient organisation for systemic autoimmune diseases, Utrecht, the Netherlands; and Federation of European Scleroderma Associations, Brussels, Belgium.
  10. Scleroderma Society of Ontario, Hamilton; and Scleroderma Society of Canada, Ottawa, Canada.
  11. Lady Davis Inst. Med. Res., Jewish General Hosp., Montreal; Dept.of Psychiatry, Dept.of Medicine, Dept.of Epidemiology, Biostatistics and Occupational Health, Dept.of Educational & Counselling Psychology, Dept.of Psychology , McGill Univ., Montreal, Canad

and the SPIN Investigators

CER11301
2018 Vol.36, N°4 ,Suppl.113
PI 0088, PF 0094
Clinical aspects

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PMID: 30277865 [PubMed]

Received: 05/04/2018
Accepted : 02/07/2018
In Press: 29/09/2018
Published: 29/09/2018

Abstract

OBJECTIVES:
Impaired hand function in systemic sclerosis (SSc) is a primary cause of disability and contributes diminished health-related quality of life. The objective of the present study was to evaluate sociodemographic, lifestyle, and disease-related factors independently associated with hand function in SSc.
METHODS:
Patients enrolled in the Scleroderma Patient-centered Intervention Network Cohort who completed baseline study questionnaires between March 2014 and September 2017 were included. Hand function was measured using the Cochin Hand Function Scale (CHFS). Multiple linear regression analysis was used to identify independent correlates of impaired hand function.
RESULTS:
Among 1193 participants (88% female), the mean CHFS score was 13.3 (SD=16.1). Female sex (standardised regression coefficient, beta (β)=.05), current smoking (β=.07), higher BMI (β=.06), diffuse SSc (β=0.14), more severe Raynaud’s scores (β=.23), more severe finger ulcer scores (β=.23), moderate (β=0.19) or severe small joint contractures (β=.20), rheumatoid arthritis (β=0.07), and idiopathic inflammatory myositis (β=0.06) were significantly associated with higher CHFS scores (more impaired hand function). Consumption of 1–7 alcoholic drinks per week (β=-0.07) was associated with lower CHFS scores (less impaired hand function) compared to no drinking.
CONCLUSIONS:
Multiple factors are associated with hand function in SSc. The presence of moderate or severe small joint contractures, the presence of digital ulcers, and severity of Raynaud’s phenomenon had the largest associations. Effective interventions are needed to improve the management of hand function in patients with SSc.

Rheumatology Article