Diagnosis
Anti-myeloperoxidase antibody positivity in patients without primary systemic vasculitis
M. Antonelou1, L. Perea Ortega2, J. Harvey3, A.D. Salama4
- UCL Centre for Nephrology, Royal Free Hospital, London, UK.
- UCL Centre for Nephrology, Royal Free Hospital, London, UK.
- Clinical immunology Laboratory, Royal Free NHS Trust, London, UK.
- UCL Centre for Nephrology, Royal Free Hospital, London, UK. a.salama@ucl.ac.uk
CER11305
2019 Vol.37, N°2 ,Suppl.117
PI 0086, PF 0089
Diagnosis
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PMID: 30767872 [PubMed]
Received: 05/04/2018
Accepted : 18/06/2018
In Press: 14/02/2019
Published: 21/05/2019
Abstract
OBJECTIVES:
We aimed to elucidate the frequency and associations of MPO-ANCA positivity in patients without ANCA-associated vasculitis (AAV), in a large urban, multi-ethnic teaching hospital.
METHODS:
Retrospective review of 200 patients identified as MPO-ANCA positive over a five-year period at Royal Free Hospital, London, UK.
RESULTS:
The incidence of anti-MPO positivity in patients without AAV was 39.5%. Gastrointestinal tract disorders, infections and other connective tissue disorders made up the majority of diagnoses, and there was a higher incidence of other concomitant autoantibodies compared to the group with known AAV. Renal disease was common in non-vasculitic patients with anti-MPO antibody positivity (occurring in 48%), the majority of whom went on to renal biopsy to exclude vasculitic involvement.
CONCLUSIONS:
The high incidence of MPO-ANCA positivity in patients with non-vasculitic conditions highlights the need for careful clinical correlation and confirmatory tissue diagnosis.
