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Anti-myeloperoxidase antibody positivity in patients without primary systemic vasculitis


1, 2, 3, 4

 

  1. UCL Centre for Nephrology, Royal Free Hospital, London, UK.
  2. UCL Centre for Nephrology, Royal Free Hospital, London, UK.
  3. Clinical immunology Laboratory, Royal Free NHS Trust, London, UK.
  4. UCL Centre for Nephrology, Royal Free Hospital, London, UK. a.salama@ucl.ac.uk

CER11305
2019 Vol.37, N°2 ,Suppl.117
PI 0086, PF 0089
Diagnosis

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PMID: 30767872 [PubMed]

Received: 05/04/2018
Accepted : 18/06/2018
In Press: 14/02/2019
Published: 21/05/2019

Abstract

OBJECTIVES:
We aimed to elucidate the frequency and associations of MPO-ANCA positivity in patients without ANCA-associated vasculitis (AAV), in a large urban, multi-ethnic teaching hospital.
METHODS:
Retrospective review of 200 patients identified as MPO-ANCA positive over a five-year period at Royal Free Hospital, London, UK.
RESULTS:
The incidence of anti-MPO positivity in patients without AAV was 39.5%. Gastrointestinal tract disorders, infections and other connective tissue disorders made up the majority of diagnoses, and there was a higher incidence of other concomitant autoantibodies compared to the group with known AAV. Renal disease was common in non-vasculitic patients with anti-MPO antibody positivity (occurring in 48%), the majority of whom went on to renal biopsy to exclude vasculitic involvement.
CONCLUSIONS:
The high incidence of MPO-ANCA positivity in patients with non-vasculitic conditions highlights the need for careful clinical correlation and confirmatory tissue diagnosis.

Rheumatology Article