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Cytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6

1, 2, 3, 4, 5, 6, 7, 8, 9, 10

  1. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, and Doctoral Program in Biomedical Sciences, Universidad del Rosario, Bogotá, Colombia.
  2. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  3. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  4. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  5. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  6. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  7. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  8. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  9. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  10. Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia. juan.anaya@urosario.edu.co

CER11385 Submission on line
2019 Vol.37, N°4 ,Suppl.119 - PI 0015, PF 0022
Aetiopathogenesis

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Rheumatology Article
Rheumatology Article

 

Abstract

OBJECTIVES:
Resilience, the ability to respond positively to adverse events, may be influenced by long-term stressors and autoimmune/inflammatory conditions such as systemic sclerosis (SSc). Since the immune system plays a role in the development of resilience, we aimed to evaluate the relationship between a panel of cytokines and resilience in patients with SSc.
METHODS:
Thirty-five consecutive women with established SSc were involved in this exploratory study. Clinical characteristics, including severity of symptoms and resilience, a panel of 15 serum cytokines and 17 autoantibodies were assessed simultaneously. Multivariate methods were used to analyse the data.
RESULTS:
Interleukin-6 (IL-6) levels were associated with severity of symptoms (β=1.8395, p=0.04), and low resilience scores (β= -0.581120, p=0.02). Furthermore, resilience was not associated with clinical manifestations nor polyautoimmunity. Cytokine levels did not significantly differ between groups based on regular physical activity.
CONCLUSIONS:
The results highlight the importance of IL-6 as a key mediator in the altered cytokine network of SSc.

PMID: 30652681 [PubMed]

Received: 07/05/2018 - Accepted : 03/09/2018 - In Press: 10/01/2019 - Published: 03/10/2019