M. Rojas1, Y. Rodríguez2, D. Monsalve3, Y. Pacheco4, Y. Acosta-Ampudia5, M. Rodríguez-Jimenez6, N. Molano-González7, R. Mantilla8, C. Ramírez-Santana9, J. Anaya10
2019 Vol.37, N°4 ,Suppl.119 - PI 0015, PF 0022
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Resilience, the ability to respond positively to adverse events, may be influenced by long-term stressors and autoimmune/inflammatory conditions such as systemic sclerosis (SSc). Since the immune system plays a role in the development of resilience, we aimed to evaluate the relationship between a panel of cytokines and resilience in patients with SSc.
Thirty-five consecutive women with established SSc were involved in this exploratory study. Clinical characteristics, including severity of symptoms and resilience, a panel of 15 serum cytokines and 17 autoantibodies were assessed simultaneously. Multivariate methods were used to analyse the data.
Interleukin-6 (IL-6) levels were associated with severity of symptoms (β=1.8395, p=0.04), and low resilience scores (β= -0.581120, p=0.02). Furthermore, resilience was not associated with clinical manifestations nor polyautoimmunity. Cytokine levels did not significantly differ between groups based on regular physical activity.
The results highlight the importance of IL-6 as a key mediator in the altered cytokine network of SSc.
PMID: 30652681 [PubMed]
Received: 07/05/2018 - Accepted : 03/09/2018 - In Press: 10/01/2019 - Published: 03/10/2019