Full Papers
Correlation between quantitative and semiquantitative magnetic resonance imaging and histopathology findings in dermatomyositis
J.C. Milisenda1, M.V. Collado2, I. Pinal-Fernandez3, A. Hormaza Jaramillo4, M. Faruch Bilfeld5, M.D. Cano6, A.I. García7, X. Tomás8, J.M. Grau9
- Muscle Research Unit, Internal Medicine Service, Hospital Clínic de Barcelona, Universidad de Barcelona IDIBAPS and CIBERER, Barcelona, Spain. jcmilise@clinic.cat
- Rheumatology Service, Instituto de Investigaciones Médicas Alfredo Lanari (UBA), Buenos Aires, Argentina.
- Muscle Diseases Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
- Rheumatology Service, Fundación Valle del Lili, Cali, Colombia.
- Radiology DepartmenT, CHU Toulouse Purpan, Toulouse, France.
- Pathology DepartmenT, Hospital Clínic de Barcelona, Spain.
- Muscle Research Unit, Radiology Department, Hospital Clínic de Barcelona, Universidad de Barcelona, Spain.
- Muscle Research Unit, Radiology Department. Hospital Clínic de Barcelona, Universidad de Barcelona, Spain
- Muscle Research Unit, Internal Medicine Service, Hospital Clínic de Barcelona, Universidad de Barcelona IDIBAPS and CIBERER, Barcelona, Spain
CER11412
2019 Vol.37, N°4
PI 0633, PF 0640
Full Papers
PMID: 30620292 [PubMed]
Received: 21/05/2018
Accepted : 18/09/2018
In Press: 19/12/2018
Published: 27/06/2019
Abstract
OBJECTIVES:
The aim of this study was to compare muscle biopsy findings, as well as clinical and analytical features, with those of magnetic resonance imaging (MRI) studies of muscle in patients with dermatomyositis.
METHODS:
All patients from the Longitudinal Myopathy Cohort of the Hospital Clínic de Barcelona were prospectively included in the study from 2009 to 2016. MRI images of muscle and fascial oedema were compared with muscle pathology results using both quantitative and semi-quantitative scores.
RESULTS:
We found a statistically significant association between the inflammatory infiltrate and both muscle (r2=0.54, p=0.001) and fascial oedema (r2=0.54, p<0.001). In addition, muscle oedema was significantly associated with punched-out vacuoles (p=0.04) and muscle enzymes in serum (r2=0.34, p=<0.01 for CK and r2=0.22, p<0.05 for aldolase). The number of treatment drugs received at the time of MRI was inversely associated with the number of muscle inflammatory cells in the biopsy and with both muscle and fascial oedema (all p<0.05).
CONCLUSIONS:
Key MRI findings correlate with the main features of dermatomyositis muscle biopsy results, suggesting that MRI findings could be used as a surrogate marker of disease activity.
