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Fibromyalgia in patients with rheumatoid arthritis. A 10-year follow-up study, results from the Oslo Rheumatoid Arthritis Register


1, 2, 3, 4, 5, 6

 

  1. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. sellaprovan@gmail.com
  2. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  3. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  4. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  5. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  6. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.

CER11523
2019 Vol.37, N°1 ,Suppl.116
PI 0058, PF 0062
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PMID: 30620293 [PubMed]

Received: 15/07/2018
Accepted : 05/11/2018
In Press: 08/01/2019
Published: 08/02/2019

Abstract

OBJECTIVES:
To examine cross-sectional and longitudinal relationships between fibromyalgia (FM) and rheumatoid arthritis (RA) disease activity.
METHODS:
636 patients in the observational Oslo RA register (ORAR) were invited to a clinical examination in 1999. 28-tender and swollen joint counts (TJC, SJC) and 18-tender points were assessed, the RA disease activity score (DAS-28) calculated. Fibromyalgia (FM) was diagnosed according to 1990 (FM-1990) and modified 2011 (mFM-2011) ACR criteria. At the 10-year follow-up patients completed the RA Disease Activity Index (RADAI) and Routine Assessment of Patient Index Data 3 (RAPID-3). Baseline and 10-year RA disease activity were compared across presence/absence of FM. Linear regression models were constructed with 10-year RADAI and RAPID-3 as outcome.
RESULTS:
502 patients participated at baseline data-collection and 10-year data was available in 236. At baseline, mean (SD) age was 59.5 (12.5) years and 87% were female. 9% and 30% had FM-1990 and mFM-2011 respectively. RA-FM patients were predominantly female with higher SJC, TJC, and DAS-28 at baseline. Baseline RA-FM predicted higher levels of RADAI and RAPID-3 at the 10-year follow-up.
CONCLUSIONS:
RA-FM was associated with significantly higher levels of cross-sectional and longitudinal RA disease activity. FM should be considered in patients with RA not reaching remission.

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