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Observational study on the QUality of life of Italian Axial SpondyloARthritis patients (QUASAR): baseline data

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34

 

  1. Rheumatology Institute of Lucania (IRel) and the Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza and Matera, Italy. saldangelo@katamail.com
  2. Rheumatology Inst.of Lucania (IRel) & Rheumatology Dept.of Lucania, San Carlo Hosp. of Potenza and Madonna delle Grazie Hosp. of Matera, Potenza & Matera, and PhD Scholarship in Life Sciences, Dept.Health Sciences, Univ.Catanzaro 'Magna Graecia', Italy.
  3. AbbVie Srl, Roma, Italy.
  4. AbbVie Srl, Roma, Italy.
  5. AbbVie Srl, Roma, Italy.
  6. AbbVie Srl, Roma, Italy.
  7. Programma Dipartimentale 'Gestione delle Malattie Reumatiche e del Connettivo e Malattie Metaboliche dell'Osso', Dipartimento Cardio-Toraco Vascolare AOU Policlinico S. Orsola-Malpighi, Bologna, Italy.
  8. Programma Dipartimentale 'Gestione delle Malattie Reumatiche e del Connettivo e Malattie Metaboliche dell'Osso', Dipartimento Cardio-Toraco Vascolare AOU Policlinico S. Orsola-Malpighi, Bologna, Italy.
  9. U.O.S. di Reumatologia, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
  10. U.O.S. di Reumatologia, Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
  11. S.S.D. Reumatologia A.S.O. Santa Croce e Carle, Cuneo, Italy.
  12. S.S.D. Reumatologia A.S.O. Santa Croce e Carle, Cuneo, Italy.
  13. U.O.C. di Reumatologia USL-IRCCS Reggio Emilia, and University of Modena and Reggio Emilia, Italy.
  14. U.O.C. di Reumatologia USL-IRCCS Reggio Emilia, Italy.
  15. U.O.C. di Reumatologia, Università Federico II Napoli, Italy.
  16. U.O.C. di Reumatologia, Università Federico II Napoli, Italy.
  17. Rheumatology Unit, Department of Medicine DIMED, University of Padova, Italy.
  18. Rheumatology Unit, Department of Medicine DIMED, University of Padova, Italy.
  19. U.O. Reumatologia-P.O. “Vito Fazzi”, Lecce, Italy.
  20. U.O. Reumatologia-P.O. “Vito Fazzi”, Lecce, Italy.
  21. Rheumatology Unit, Department of Clinical and Experimental Medicine, A.O.U. and University of Sassari, Italy.
  22. Rheumatology Unit, Department of Clinical and Experimental Medicine, A.O.U. and University of Sassari, Italy.
  23. U.O.S.D. di Reumatologia, Ospedale S. Giovanni Bosco, Napoli, Italy.
  24. U.O.S.D. di Reumatologia, Ospedale S. Giovanni Bosco, Napoli, Italy.
  25. U.O.C. Reumatologia, Azienda Ospedaliero-Universitaria S. Anna, Ferrara (loc. Cona), Dip. Scienze Mediche Università di Ferrara, Italy.
  26. U.O.C. Reumatologia, Azienda Ospedaliero-Universitaria S. Anna, Ferrara (loc. Cona), Dip. Scienze Mediche Università di Ferrara, Italy.
  27. U.O.S. di Reumatologia A.O.R.N. Cardarelli, Napoli, Italy.
  28. U.O.S. di Reumatologia A.O.R.N. Cardarelli, Napoli, Italy.
  29. Dipartimento di Medicina, Ospedale S. Gerardo - ASST Monza, Italy.
  30. Dipartimento di Medicina, Ospedale S. Gerardo - ASST Monza, Italy.
  31. Rheumatology Research Unit, Dipartimento Scienze della Salute, Policlinico Universitario Mater Domini, Catanzaro, Italy.
  32. Rheumatology Research Unit, Dipartimento Scienze della Salute, Policlinico Universitario Mater Domini, Catanzaro, Italy.
  33. Reumatologia Day Hospital, A.S.S. Gaetano Pini-CTO, Milano, Italy.
  34. Reumatologia Day Hospital, A.S.S. Gaetano Pini-CTO, Milano, Italy.

CER11557
2019 Vol.37, N°5
PI 0748, PF 0755
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PMID: 30943145 [PubMed]

Received: 23/07/2018
Accepted : 12/11/2018
In Press: 02/04/2019
Published: 29/08/2019

Abstract

OBJECTIVES:
To describe the baseline characteristics of the patients enrolled in the QUality of life in patients with Axial SpondyloARthritis (QUASAR) study in terms of quality of life (QoL), disease activity, therapy adherence, and work ability in a real-world setting.
METHODS:
QUASAR is an Italian multicentre, prospective 12-month observational study, including consecutive adult patients classified as axial spondyloarthritis (axSpA) according to the Assessment of SpondyloArthritis international Society criteria for axSpA.
RESULTS:
Of 512 patients enrolled in 23 rheumatology centres, 80.7% had ankylosing spondylitis (AS) and 19.3% had non-radiographic axSpA (nr-axSpA). Mean ages were 34.1±13.3 years at axSpA symptoms onset and 39.5±13.0 years at diagnosis. Of the patients, 51.4% presented with ≥1 extra articular manifestation (EAM); the most common were psoriasis (17.8%) and uveitis (16.4%). Patients with nr-axSpA and AS had similar EAM rates, disease activity, and QoL. Biologic disease-modifying anti-rheumatic drugs (bDMARDs; 83.2%) were the most commonly received medication, followed by conventional synthetic DMARDs (22.9%) and non-steroidal anti-inflammatory drugs (NSAIDs; 16.6%). At baseline, higher treatment satisfaction was reported with bDMARDs which, together with NSAIDs, were associated with the best overall scores for disease activity, function, and QoL in the overall population and AS subgroup.
CONCLUSIONS:
QUASAR is the first Italian prospective study that comprehensively evaluated a large axSpA patient sample in a real-world setting. This interim analysis at baseline confirmed that i) patients with AS and nr-axSpA have similar QoL and disease burden, ii) nearly all axSpA patients receive treatment, and iii) bDMARDs and NSAIDs, overall, yield better disease activity and QoL.

Rheumatology Article