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Cytokine expression in temporal arteries: comparative analysis between patients with biopsy-positive giant cell arteritis, biopsy-negative giant cell arteritis and biopsy-negative without arteritis


1, 2, 3, 4, 5, 6

 

  1. Department of Internal Medicine F and the Rheumatology Unit, The Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel. chagaigr@gmail.com
  2. Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  3. Department of Pathology, The Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  4. Department of Internal Medicine B, Tel Aviv Sourasky Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  5. Department of Internal Medicine F and the Rheumatology Unit, The Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  6. Department of Pathology, The Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.

CER12110
2019 Vol.37, N°2 ,Suppl.117
PI 0122, PF 0129
Diagnosis

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PMID: 31162032 [PubMed]

Received: 24/01/2019
Accepted : 02/05/2019
In Press: 21/05/2019
Published: 21/05/2019

Abstract

OBJECTIVES:
To investigate whether expression of pro-inflammatory cytokines in the temporal artery may aid in differentiating biopsy-negative giant cell arteritis (GCA) patients from those with a negative biopsy without arteritis.
METHODS:
We investigated cytokine expression in temporal artery biopsy (TAB) of 54 consecutive patients: 17 with biopsy-positive GCA, 17 with biopsy-negative GCA, and 20 biopsy-negative without arteritis. We compared the expression rate of the following cytokines among these 3 groups of patients: interleukin-6 (IL-6), osteopontin (OPN), COX-2, and TNF-α.
RESULTS:
IL-6 was expressed in 13 (76%) patients with biopsy-positive GCA, 0 patients in biopsy-negative GCA, and 1(5%) patient with biopsy-negative without arteritis (p<0.05). OPN was expressed in 17 (100%) patients with biopsy-positive GCA, 2 (12%) patients with biopsy-negative GCA, and 0 patients with biopsy-negative without arteritis (p<0.05). Cox-2 was expressed in 16 (94%) patients with biopsy-positive GCA, 0 patients with biopsy-negative GCA, and 3 (15%) patients with biopsy-negative without arteritis (p<0.05). TNF- α was expressed in 17 (100%) patients with biopsy-positive GCA, 14 (82%) patients with biopsy-negative GCA, and 8 (40%) patients with biopsy-negative without arteritis (p<0.05).
CONCLUSIONS:
IL-6, COX-2 and OPN are significantly more expressed in the presence of a positive TAB compared to a negative TAB. TNF-α is significantly more expressed in GCA patients compared to non-GCA patients. Thus, TNF-α expression may suggest a diagnosis of GCA despite a negative TAB. Further larger studies are needed to confirm these findings.

Rheumatology Article