Brief Papers
Does psoriatic axial spondyloarthritis phenotype correlate with imaging morphotype?
L.S. Gensler1, A. Szumski2, H.E. Jones3, X. Baraliakos4
- University of California, San Francisco, CA, USA. lianne.gensler@ucsf.edu
- Syneos Health, Collegeville, PA, USA.
- Pfizer, Collegeville, PA, USA.
- Ruhr University, Rheumazentrum Ruhrgebiet Herne, Bochum, Germany.
CER12220
2020 Vol.38, N°2
PI 0329, PF 0332
Brief Papers
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PMID: 31577217 [PubMed]
Received: 08/03/2019
Accepted : 08/07/2019
In Press: 01/10/2019
Published: 26/03/2020
Abstract
OBJECTIVES:
To compare the magnetic resonance imaging (MRI) morphology of inflammatory and chronic lesions in the sacroiliac joints (SIJs) and spine between patients with non-psoriatic and psoriatic non-radiographic axial spondyloarthritis (axSpA and p-axSpA, respectively).
METHODS:
Patients from the EMBARK trial (NCT01258738) with axSpA (n=179) and p-axSpA (n=24) who had MRI data available were compared in terms of baseline demographics, clinical characteristics, and the frequency (n/N [%]) and distribution of inflammatory and structural SIJ and spinal lesions.
RESULTS:
Patients with p-axSpA were on average older (35.1 years vs. 31.7 years, p=0.047), had a higher occurrence of asymmetric sacroiliitis (54.2% vs. 29.6%, p=0.042), and a lower occurrence of human leukocyte antigen (HLA)-B27 positivity (41.7% vs. 73.7%, p=0.010) than patients with axSpA. There were no significant differences in the frequency of lesions in any of the SIJ or spinal quadrants between the two subgroups.
CONCLUSIONS:
These data suggest that differences between axSpA and p-axSpA extend beyond presence of psoriasis, and include age, SI symmetry, and HLAB27 status. These findings may help explain the morphotype-phenotype relationship across axSpA, similar to those described in older radiographic studies.