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Paediatric Rheumatology

 

Acute rheumatic fever prophylaxis in high-income countries: clinical observations from an Italian multicentre, retrospective study

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17

 

  1. University of Trieste and Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy. andrea.taddio@burlo.trieste.it
  2. University of Trieste, Italy.
  3. Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy.
  4. Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy.
  5. Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy.
  6. Department of Paediatrics, University of Chieti, Italy.
  7. University of Trieste, Italy.
  8. Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy.
  9. University Department Pro.Sa.M.I. G. D'Alessandro, University of Palermo, Italy.
  10. Paediatric Rheumatology, Anna Meyer Children University Hospital, Florence, Italy.
  11. Department of Paediatrics, University of Chieti, Italy.
  12. Paediatric Rheumatology, Anna Meyer Children University Hospital, Florence, Italy.
  13. Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, Italy.
  14. Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, Italy.
  15. Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, Italy.
  16. Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, Italy.
  17. University of Trieste and Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy.

for the Italian Paediatric Rheumatology Study Group

CER12313
2020 Vol.38, N°5
PI 1016, PF 1020
Paediatric Rheumatology

purchase article

PMID: 31969217 [PubMed]

Received: 09/04/2019
Accepted : 18/10/2019
In Press: 20/01/2020
Published: 02/10/2020

Abstract

OBJECTIVES:
The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of rheumatic heart disease (RHD) in a cohort of Italian patients with acute rheumatic fever (ARF).
METHODS:
This is a multicentre retrospective study. The patients were divided into two groups by the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated.
RESULTS:
Two-hundred and ninety patients were enrolled (137 females; 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients manifested RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p=0.001), but it was not related to secondary prophylaxis adherence (p=NS). No association between prophylaxis adherence and ARF recurrence was found (p=NS) nor between ARF recurrence and RHD at the end of follow-up (p=NS).
CONCLUSIONS:
Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm our data in a larger population.

Rheumatology Article