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Spinal mobility in the cervical and lumbar spine correlates with magnetic resonance imaging findings for inflammatory and structural changes in patients with active ankylosing spondylitis

1, 2, 3, 4, 5

 

  1. Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Germany. xenofon.baraliakos@elisabethgruppe.de
  2. Radiology, Charité Universitätsmedizin, Berlin, Germany.
  3. Janssen Research & Development, LLC, Spring House, PA, USA.
  4. Janssen Research & Development, LLC, Spring House, PA, USA.
  5. Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Germany.

CER12325
2020 Vol.38, N°3
PI 0467, PF 0471
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PMID: 32242806 [PubMed]

Received: 12/04/2019
Accepted : 08/07/2019
In Press: 03/04/2020
Published: 26/05/2020

Abstract

OBJECTIVES:
We aimed to assess relationships between single Bath Ankylosing Spondylitis Metrology Index (BASMI) components and corresponding spinal segment magnetic resonance images (MRI) in anti-tumour-necrosis-factor-treated AS patients.
METHODS:
Using available MRI and BASMI data from the GO-RAISE trial (n=91 patients), MRI scores for active inflammatory (ASspiMRI-a) and chronic structural (ASspiMRI-c) changes in cervical and lumbar spine segments were compared with BASMI cervical (cervical-rotation [CR] angle, tragus-to-wall [TTW] distance) and lumbar (lumbar flexion [LF], lateral-lumbar-flexion [LLF]) spine component scores (linear definition). Generalised linear models were employed to assess relationships between BASMI components and ASspiMRI-a/ASspiMRI-c measurements at baseline and for week-14 (golimumab/placebo groups) and week-104 (all golimumab-treated) change scores.
RESULTS:
Baseline lumbar ASspiMRI-a scores correlated with LF and LLF (β=0.231 and 0.238, respectively; both p<0.01), while this was less prominent for ASspiMRI-c scores and LLF (β=0.142, p=0.04). A significant but weak correlation was found between changes from baseline to week 104 in cervical spine ASspiMRI-c score and TTW distance among all treated patients (β=0.161, p=0.003).
CONCLUSIONS:
Detailed assessments indicated baseline spinal mobility impairment in patients with active AS correlated weakly with MRI-detected lumbar spinal inflammation; correlations with chronic, structural damage/changes were very weak. Improved, less variable MRI and spinal metrology assessments are needed for future clinical research.

Rheumatology Article